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The results of ACHIEVE-3 highlight the potential advantages of orforglipron over oral semaglutide for Type 2 diabetes: greater A1c reduction, more weight loss and the ability to take it without food or water timing restrictions thats a combination that could matter significantly to people managing their disease day in and day out, said Kenneth Custer, Ph.D., executive vice president and president of Lilly Cardiometabolic Health

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Currently, there are other dual GIPR/GLP-1R agonists available, such as GLP-1R/GR (glucagon receptor), GLP-1R/AR (amylin receptor), and GLP-1R/NPYR (peptide YY binds to neuropeptide Y receptors) [36, 115] and even triple agonists that can activate GIPR to treat obesity and T2DM

After First Puncture Once the rubber stopper has been punctured, the 28-day rule applies