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In June 2025, Eli Lilly reported Phase III ACHIEVE-1 Survodutide (BI 456906): Boehringer Ingelhium Survodutide (BI 456906) is a GCGR/GLP1 dual agonist being developed by Boehringer Ingelhium

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However GIP did not show efficacy in diabetic patients so the search continued (1)

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The concept of treating two conditions (diabetes and obesity) with one shot is very appealing

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One of the ongoing debates about this entire class of medications is whether the effects are mediated solely by weight loss and mitigation of the inflammatory consequences of energy toxicity (read: too many calories) versus other biological effects of these medications

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GLP1 Drugs (Wegovy, Zepbound): Pros: Highly effective, non-invasive, strong appetite suppression, rapid results

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Regulators in the US and Europe have extended approvals to adolescents with obesity, and a July 2026 review published in Digestive and Liver Disease by Abodi, Agostoni, and Mazzocchi surveys the trial evidence behind those approvals, the safety signals to watch, and the gaps the field has yet to close [1]

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