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Yet, contrary to these findings, metformin does not directly inhibit DPP-4 activity in vitro [9, 14, 16]

Rybelsus (semaglutide tablets) [package insert]

The rising use of GLP-1 RAs is accompanied by growing interest in their potential non-metabolic effects, including a possible impact on cancer risk

25.Eli Lilly and Company Mounjaro (tirzepatide) summary of product characteristics

b) Same plot for semaglutide

In addition to acting through the p38 pathway, GLP-1RAs also promote the increase of PKA levels via the cAMP-dependent pathway, which in turn prevents the phosphorylation of epidermal growth factor receptor (EGFR) and activator of transcription 3 (STAT3), resulting in the inactivation of the EGFR-STAT3 signaling pathway in tumor cells and subsequently downregulating several downstream effector genes such as myelocytomatosis oncogene (c-Myc), survivin, cyclin D1, Bcl-xl, and Bcl-2, thereby inducing apoptosis in tumor cells in a dose-dependent manner [70, 73]