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It is the first weight-loss medication ever to carry a CV-risk-reduction indication

[ [PMID: 32174887] [ [PMID: 36992862] [ [PMID: 35832567] et al
The sponsor inconsistently applied costs for treatments that included metformin and those that did not

Research on incretin medications demonstrates that weight regain occurs for most users after discontinuation because the medication suppresses metabolic adaptations that defend higher body weight

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