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56 These trials demonstrate that although orforglipron is safe and efficacious more longitudinal research is warranted to provide deeper insights into their efficacy, safety and tolerability before their potential incorporation in the pharmacological arsenal against T2DM or obesity

Treatment typically begins with a 0.25 mg weekly dose for four weeks as a starter dose for tolerability only, then increases to 0.5 mg once weekly for glycaemic control

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Extended-release formulations are typically avoided initially and should never be crushed or split

Mechanisms by Which Adiponectin Reverses High Fat Diet-Induced Insulin Resistance in Mice