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While the study concluded that the clinical benefit was independent of sex, it does appear that some of the benefits were more pronounced or more consistent in males: major adverse cardiovascular event HR 0.71 (0.58-0.88) in males vs 0.78 (0.52-1.19) for females

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Although, as expected, they had lower values than the semaglutide injectable

The results of recent work reveal that GLP-1R is expressed in neuropeptide Y (NPY)-positive neurons in the AP and that GLP-1 can directly or indirectly inhibit neuronal signaling in the anorexigenic NPY system via agonism of GLP-1R 19