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GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone in the human body that plays a critical role in regulating blood sugar levels, appetite, and insulin secretion

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The global signal, ALFF, and FCD were tested in GraphPad (version 9.5.1 GraphPad Software, LLC) using the built-in ROUT method to find outliers

Tirzepatide did not increase risks of adverse renal events, urinary tract infections, nephrolithiasis (kidney stones), acute kidney injury, or renal cancer compared to placebo, insulin, or other GLP-1 receptor agonists