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The relevance is that meaningful, sustained weight loss is one of the few lifestyle changes with strong evidence for reducing AF burden over time

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To reduce the risk of the aforementioned side effects, treatment is usually started with small doses that are gradually increased

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1 Introduction Rhabdomyolysis is characterized by the breakdown of skeletal muscle fibers, resulting in the release of intracellular contents such as myoglobin and creatine kinase (CK) into the bloodstream (Cabral et al., 2020)
