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This mechanism enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

Acute pancreatitis is a rare but potentially life-threatening adverse effect associated with GLP-1 receptor agonists, including tirzepatide

All factors are assessed by a trial clinician before and during participation

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Sheela Magge, director of pediatric endocrinology at Johns Hopkins Medicine in Baltimore, has seen an increase in cases of more severe obesity-related conditions in children, including non-alcoholic fatty liver disease

7 In 2021, the FDA approved semaglutide for chronic weight management in obese/overweight adults with at least one weight-related condition