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This is thought to be due to its ability to activate multiple receptors, including the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide receptor, which work together to regulate blood sugar levels and insulin secretion

The STEP (Semaglutide Treatment Effect in People with obesity) trials, which included over 4,500 participants, showed that semaglutide 2.4 mg weekly resulted in mean weight loss of 12.4% to 15.3% of initial body weight over 68 weeks, compared to 2.4% to 3.2% with placebo

Consistent with other GLP1RA studies, gastrointestinal disorders were the most commonly reported AEs leading to trial product discontinuation, with most occurring during the doseescalation period

I have had no side effects

doi: 10.1002/ajmg.a.61304 28 DudleyOMuscatelliF

Gallbladder Effects Even small doses of curcumin (20-80 mg) can stimulate gallbladder contractions and could increase pain during stone passage or potentially increase perforation risk in people with gallstones [121]