glp 1 gut hormone Health Feed A sympathetic brake on gut

The Biology of GLP-1 and Why It Matters in Midlife GLP-1 (glucagon-like peptide-1) is a gut hormone, secreted after meals, that signals satiety, slows gastric emptying, and enhances insulin release

Anticancer Drugs 30(10):991997 Nomura M et al (2020) Association of short-chain fatty acids in the gut microbiome with clinical response to treatment with nivolumab or pembrolizumab in patients with solid cancer tumors

191,192 In vascular endothelial cells, GLP-1R activation stimulates endothelial nitric oxide synthase (eNOS), promoting nitric oxide (NO) production and improving endothelium-dependent vasodilation

Click here Image Credit : Phispers Infographic by PharmaCompass license under CC BY 2.0 The article is based on the information available in public and which the author believes to be true

Although CNO is often used as the inert ligand for DREADDs, studies show minimal, yet significant, reverse metabolism to clozapine, an active metabolite which could bind to non-DREADD receptors and produce off-target effects on behavior 31

Focus on the trajectory over weeks and months, not individual weigh-ins