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Alternative delivery methods Some users experiencing stalls on injectable GLP-1 medications explore alternative delivery routes

Shekhar S, Copacino CE, Barrera FJ, Hall JE, Hannah-Shmouni F

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It becomes protease-resistant by changing the amino acid at position 8 and an extended spacer for the attached fatty acid which prolongs the half-time in the blood (164), and is a once-weekly GLP-1R agonist for T2DM

In one notable example, the company rejected a CAPA request related to burnt electrodes with air pockets, despite the nonconformance potentially causing "arcing and burning a patient." The rejection was justified because it was "the first-time instance of such an event," even though the issue carried significant patient risk

doi: 10.1038/s41569-021-00536-1, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 83