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In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.

Background Alcohol use disorder (AUD) affects nearly half a billion people globally and is associated with significant physical and psychiatric comorbidities

Los adultos que recibieron la dosis ms alta de orforglipron en el estudio clnico ATTAIN-1 perdieron una media de 12,4 kg.

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