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Meta-analysis of trials in overweight/obese subjects found that once-weekly semaglutide (2.4 mg) significantly reduced fasting total cholesterol, low-density lipoprotein cholesterol (LDL-C), VLDL-cholesterol, and triglycerides (TG), while modestly raising high-density lipoprotein (HDL) cholesterol [56]

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However, the co-expression of T2Rs with enteroendocrine cells containing other hormones is not well characterized in rodents or humans

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