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Moreover, following surgically-induced weight loss in morbid obesity, the elevated adipocyte DPP-4 release, and circulating DPP-4 levels were both substantially reduced, further suggesting that the adipose tissue is likely to be a major source of plasma DPP-4 (79)
So if you have 40 pounds to lose, your target is reduced by an additional 80 calories per day

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Comparative safety and side effects of semaglutide and tirzepatide: implications for clinical decision-making in obesity management
