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GLP-1 RAs also improve insulin sensitivity, reduce ectopic fat deposition, and modulate adipose tissue metabolism by stimulating lipolysis and inhibiting lipogenesis [12, 13]

Ten-year follow-up in Sleep AHEAD

Marx N, Burgmaier M, Heinz P, Ostertag M, Hausauer A, Bach H, et al

Atypical antipsychotics with a low metabolic risk, including aripiprazole, brexpiprazole, cariprazine, lurasidone, and ziprasidone, will minimize weight gain (Musil R et al, Expert Opin Drug Saf 2015;14(1):7396)

However, that is not the reality: even diabetic patients treated with GLP-1 RAs are more likely to stop them than other second-line anti-diabetic medicines

injected once weekly Wegovy (semaglutide) Long-acting