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However, the starting dose itself is not considered a full therapeutic level

GLP-1s Direct Biological Impact in the Brain Beyond their systemic metabolic effects, GLP-1 medications exert direct biological actions in the brain through widespread expression of incretin (GLP-1) receptors in regions critical for cognition, including the hippocampus, prefrontal cortex, and hypothalamus [14]

However, when used with insulin or sulfonylureas, dose adjustments of these agents may be needed to prevent hypoglycemia, as with all GLP-1 receptor agonists

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Traditionally, the treatment of metabolic hypogonadism in patients with obesity has relied on testosterone replacement therapy, primarily due to the challenges of achieving substantial weight loss through lifestyle changes alone in real-world settings