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GLP-1 may help improve BBB function in these diseases by reducing oxidative stress and inflammation

GLP-1RAs do not broadly cross the blood-brain barrier, but they can access neurons in the CVOs and in a few select sites in the hypothalamus [89]

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doi: 10.2337/db18-0729 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Mller TD, Finan B, Bloom SR, et al

Therefore, whether lactate can promote fibroblast activation via NLRP3 inflammasome was investigated by exogenous lactate treatment and NLRP3 knockdown

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