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The very mechanism that makes these drugs effectiveappetite suppression 1 can make it difficult to consume the increased amount of protein required for muscle preservation during weight loss and exercise

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GI adverse events that occurred in postmenopausal women with operable breast cancer who received adjuvant tamoxifen therapy (n = 3094) in the ATAC trial include nausea and vomiting (12%), nausea (11%), abdominal pain (9%), constipation (8%), diarrhea (7%), dyspepsia (6%), and GI disorder (5%)

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These compounds offer the potential for greater convenience, improved tissue penetration, longer half-lives, and lower production costs

But analysis and reports show that drugs used for weight loss aren't often covered by Medicare, most Medicaid programs, and some commercial insurances, limiting access to the drugs which can cost over $1,300 out of pocket for a month's supply
