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For semaglutide, this means the drug may remain detectable in your system for approximately 56 weeks after the final injection, though therapeutic effects diminish sooner

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Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus

Most individuals first notice reduced appetite, increased fullness, and lower food intake in the first few weeks, while more visible body changes, such as reduced waist circumference and improved mobility, often appear after 2-5 months

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