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Importantly, recent research suggests that paternal preconception interventions, such as dietary restriction or exercise, may restore sperm epigenetic integrity and reduce offspring metabolic risk [103]

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doi: 10.1210/en.2013-1934 29 MuscogiuriGDeFronzoRAGastaldelliAHolstJJ

15 Conclusions In conclusion, the available data on endocrine disorders associated with PWS suggest that there is no clear genotype-phenotype association