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Description
The study showed that the renal extraction of GLP-1, natriuretic effect of GLP-1 and change of plasma concentrations of ANG II was abolished by the GLP-1 receptor antagonist Exendin 939 (Ex 939), suggesting that GLP-1-induced natriuresis is dependent on GLP-1 receptor activation 38

Most other GLP-1 agonists, such as semaglutide (Ozempic), only target the GLP-1 receptor
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Patients who may derive particular benefit include: Individuals with type 2 diabetes and mixed dyslipidaemia : Those with elevated triglycerides and modest LDL cholesterol elevation alongside diabetes may experience improvements in multiple cardiovascular risk factors simultaneously

All CRISPR alleles were verified by sequencing and outcrossed 24 times with wild type prior to analysis
