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Further research is needed to more clearly elucidate both if GLP-1-mediated glucose uptake in hepatic tissue is exclusively through extrahepatic GLP-1R activation and if GLP-1R is distributed in human hepatic tissue

Dose adjustments are performed according to tolerability and routine clinical guidelines

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Acknowledgements Medical writing and editorial assistance was provided by Andy Bond and Emma Marshman of Spirit Medical Communications Ltd, and was supported by Novo Nordisk A/S