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In alignment with American College of Rheumatology and American College of Physicians guidelines, first-line management for osteoarthritis includes exercise and weight loss

Survodutide : GI adverse events in 75% of survodutide vs 42% placebo in Phase 2

The drugs also seem to reduce inflammation, which may help to reduce risk of cancer

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Treatment with sitagliptin (20 mg/kg) increased serum GLP-1 levels in STZ-induced diabetic monkeys and showed significantly protective effects on STZ-induced islet injury in vivo and in vitro via activation of the insulin-like growth factor receptor (IGFR)/AKT/mammalian target of rapamycin (mTOR) signaling pathways [47]