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Some patients achieve doubledigit percentage weight loss over several months when medication is combined with lifestyle changes

In addition to reduction in A1C and body weight, the semaglutide 2.0 mg arm of the trial saw a greater proportion of patients achieve an A1C less than 7% (67.6% vs 57.5% [OR, 1.60

For people who find injections uncomfortable, this might not be worth it

Consider a thiazide diuretic, an ACE inhibitor, an ARB, or a calcium channel blocker

The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52

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