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Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: A 26-week prospective real-life study

Presented at #ECO2025: In the SURMOUNT-5 phase 3b trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference

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Potential for Smoking Cessation: Semaglutide users were less likely to have medical encounters involving a diagnosis of tobacco use disorder, prescribing of smoking cessation medication, or smoking cessation counseling, indicating a potential benefit for smoking cessation

Studies on GLP-1R binding sites and c-fos activation after peripheral semaglutide did not find evidence for direct access to the midbrain (Gabery et al., 2020