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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Longo M., Zatterale F., Naderi J., Parrillo L., Formisano P., Raciti G.A., Beguinot F., Miele C

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JAK inhibitors markedly reduce inflammatory lesions and abscesses by broadly suppressing pro-inflammatory cytokine signaling, including key fibrogenic pathways such as IL-6 and IL-17, thereby limiting inflammation-driven fibrosis

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Several significant metabolite-microbe relationships were also revealed, including the glycine strong positive association with Clostridium (Zhuang et al., 2018) and homocysteine positive correlation with Lachnospira , Clostridium , and Haemophilus and its negative correlation with Corynebacterium and Lachnospiraceae (Zhuang et al., 2018)