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Serious Reactions: Hypersensitivity reaction, anaphylaxis, angioedema, acute kidney injury, chronic renal failure exacerbation, pancreatitis, cholelithiasis, cholecystitis, syncope

Trough concentrations of latent myostatin were collected through 24 weeks and during the safety follow-up period

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The dual GIP/GLP-1 receptor agonism of tirzepatide appears to be the primary protective factor, as GIP receptor activation may counterbalance some of the autonomic and vestibular effects of GLP-1 receptor stimulation

The same study also found that: 90.7% of people lose at least 5% of their starting weight 82.4% of people lose at least 10% of their starting weight 66.5% of people lose at least 15% of their starting weight 47.7% of people lose at least 20% of their starting weight 31.2% of people lose at least 25% of their starting weight On the Wegovy tablet, clinical trials have found that people lose an average 17% of their starting weight

This marked decrease in appetite may lead to insufficient energy availability for exercise, particularly during moderate to high-intensity workouts