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Most people who are on GLP-1 medications experience at least one side effect

In 2025, the company reported a modest +0.99% YoY revenue growth, but the underlying story is more interesting: Dupixent ($17.8B) remains the clear growth engine, benefiting from expanding indications like COPD and broader patient reach, while the EYLEA franchise ($7.89B) continues to be a core contributor despite facing biosimilar pressure, supported by the transition to EYLEA HD, and Libtayo ($1.45B) is steadily gaining ground in oncology, particularly in lung cancer settings

Multiple large-scale analyses of observational data, including those comparing GLP-1RAs to SGLT-2 inhibitors and other oral agents, have found no statistically significant association between GLP-1RA use and the exacerbation of DR or the development of sight-threatening retinopathy [9295]

A practical tip is to write the date of first use on the pen or carton to help track the 6-week usage period

And typically, when something is covered by public insurance programs, private payers eventually follow suit

For a broader look at the most common GLP-1 reactions, our guide to GLP-1 side effects is a helpful companion read