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On January 5, 2026, Novo Nordisk introduced oral Wegovy (semaglutide), marking the first FDA-approved oral GLP-1 therapy for chronic weight management, offering a daily pill alternative to weekly injections

In this case, the combination is being used intentionally, and the clinical goal is clear

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Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

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