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Furthermore, exendin-4 can stimulate the cyclic adenosine monophosphate/protein kinase A (cAMP-PKA) pathway by activating GLP-1R, which then increases the level of non-phosphorylated -catenin to stimulate the Wnt/-catenin/NeuroD1 pathway and inhibits the activity of GSK-3, ultimately decreasing the hyperphosphorylation of AD-associated tau proteins regulated by GSK-3 (Kang et al., 2023)

Kang CH, Jung ES, Jung SJ, Han YH, Chae SW, Jeong DY, et al

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Outcomes The study was concluded after a median follow-up of 25 months