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Description
Mimicking the initial multiple, extensive interactions with the ECD seemed implausible to achieve with smaller, non-peptide molecules

Initial studies have shown promising outcomes in weight reduction and glycemic control in patients with obesity and type 2 diabetes
Severe cases may require temporary discontinuation of the GLP-1 medication, intravenous fluid replacement, and assessment of renal function through serum creatinine and electrolyte measurements

[8] [9] Beyond pancreatic effects, these medications significantly slow gastric emptying, which prolongs the sensation of fullness after meals
Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes2025

Results Our analysis revealed that the traditional logistic regression model outperforms the other machine learning models, with an area under the Receiver Operating Characteristic curve (auROC) of 0.77.Our model showed that higher pre-treatment HbA1C is a dominant feature for predicting better response to GLP-1 M, while features such as use of thiazolidinediones or sulfonylureas is correlated with poorer response to GLP-1 M, as assessed by lowering of hemoglobin A1C (HbA1C), a standard marker of glycated hemoglobin used for assessing glycemic control in individuals with diabetes
