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efficacy of glp 1 receptor agonists Changes in weight with glucagon-like peptide (GLP-1 Comparative efficacy and safety of
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Hall Jan 2022)
Notably, the PKA inhibitor 8-Br-Rp-cAMPS attenuates the inhibitory effect of GLP-1 on glucagon secretion, suggesting that GLP-1 suppression of glucagon secretion is PKA-dependent [583]
Although these trials primarily enrolled individuals with relatively low DKD risk and were not designed to evaluate kidney outcomes specifically, exploratory analyses consistently indicated slower kidney disease progression across diverse eGFR and albuminuria levels [39-44]
& Sun, E
Chooi, Y
