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GLP-1 receptor agonists work by stimulating the release of insulin from the pancreas in a glucose-dependent manner

doi: 10.1002/jnr.490160110

This central 5-HT-GLP-1 interaction was further shown to enhance proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neuron activity, boosting satiety signals, and concomitantly suppress neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity, which diminishes hunger [22]

Hopefully, in a few years, we will have a lot more data to answer experts most pressing questions around GLP-1s and mental health

12 (2000): 68746879, 10.1073/pnas.120069197

Since GLP-1R is expressed in the cells of various organs including pancreatic -cells, GLP-1R agonists manifest favourable effects during its circulation