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(2023) 46:S128S39

Patients should be encouraged to consume a varied, nutrient-dense diet rich in: Iron found in red meat, poultry, fish, lentils, and fortified cereals Zinc present in shellfish, meat, seeds, and nuts Vitamin D obtained through sunlight exposure, oily fish, and fortified foods B vitamins , particularly B12 found in animal products and fortified alternatives For patients struggling to meet nutritional requirements through diet alone, a standard multivitamin supplement within recommended daily allowance (RDA) limits may be considered after discussion with a healthcare professional

The pharmacologic GLP-1RA semaglutide has been shown to bind GLP-1R with higher affinity than GLP-1 [76] and achieve nanomolar concentrations with pharmacologic interventions [77], suggesting that exogenous GLP-1R therapy may induce PKA-associated insulin secretion in pancreatic tissue that is not achieved with physiologic GLP-1 activity

Similar content being viewed by others Executive Summary The current report is an overview of current knowledge on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) based on pragmatic review of the available clinical evidence on use of GLP-1 RAs in the management of type 2 diabetes mellitus (T2DM)

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) for the treatment of type 2 diabetes mellitus: friends or foes to bone health

Case report data show salivary flow returning to normal within four weeks of stopping semaglutide