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Until recently, no therapeutic potential was associated with the other incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), as preclinical studies have suggested potential obesogenic effects

8,12,13 A meta-analysis by Ku and Chang 6 reported PASI improvement in both diabetic and nondiabetic groups (over the 6- to 12-week periods of the 4 prospective cohort studies analyzed), with nearly 35% achieving a 75% or greater improvement in PASI (PASI-75) from their respective baselines, and a proposed immunomodulatory mechanism

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doi: 10.1053/j.gastro.2007.03.054 [DOI] [PubMed] [Google Scholar] 24

There was a numerically higher number of gastrointestinal AEs with liraglutide, in line with previous experience with GLP-1 therapy