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When compared to other GLP-1 medicationssuch as liraglutide (Saxenda), dulaglutide (Trulicity), and exenatide (Byetta)semaglutide generally leads to more pronounced and sustained weight loss outcomes

95% CI, 0.882.56)

doi: 10.1007/s12020-019-02055-z 93 PintoLCFalcettaMRRadosDVLeitaoCBGrossJL

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Although it is still unclear why the GLP-1 response is so wasteful from a bioenergetics perspective, recent studies have suggested that the inactive GLP-1 has actions on the liver, vasculature and heart which are comparable to those of insulin 33

Acknowledgements We acknowledge the Cardiometabolic Disorders team at Amgen Research for their valuable contributions to this work
