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It causes damage to the blood vessels in the retina and may result in vision loss
For that reason, much of the care management strategies employed when prescribing GLP-1 medications borrow from evidence-based obesity care management and diabetes care management
48,49 Heart Rate Increase GLP-1RAs are known to cause a modest, dose-dependent increase in resting heart rate

However, the GLP-1 medications have some pretty intense side effects

A 39-amino-acid peptide with a fatty diacid moiety attached for half-life extension is harder to synthesize correctly than shorter, simpler peptides

Global, regional, and national burden of stroke, 19902016: a systematic analysis for the Global Burden of Disease Study 2016
