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Soon after, doctors noticed something else: the drug also reduced appetite and slowed down how quickly the stomach empties

Slow dose titration, eating smaller meals, staying hydrated, and avoiding high-fat foods substantially reduce these effects
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Nat Rev Mol Cell Biol 2 , 127137, doi:10.1038/35052073 (2001)
Persistent pain may signal a more serious underlying issue

Blood in Stool Evaluation of the presence of blood in the feces, which may indicate underlying conditions