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Treating Prader-Willi syndrome, a genetic disorder with many symptoms

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[DOI] [PubMed] [Google Scholar] 131.Harvey C.J.d.C., Schofield G.M., Zinn C., Thornley S

Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor