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Important Limitations of Use : [1] Not recommended as first-line therapy for patients inadequately controlled on diet and exercise

We see this same pattern after: Bariatric surgery Severe calorie restriction Illness or hospitalization Postpartum hormone shifts GLP-1 therapy can create a similar metabolic environment if weight loss is aggressive or nutrition is inadequate

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Korner, M., Stockli, M., Waser, B

Zhang LQ, Zhang W, Li T, Yang T, Yuan X, Zhou Y, Zou Q, Yang H, Gao F, Tian Y, Mei W, Tian XB (2021) GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-kappaB pathway in neuropathic pain mice