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Short-chain fatty acids (SCFAs) produced by gut bacteria through activation of the G protein-coupled free fatty acid receptors FFAR2 (GPR43) and FFAR3 (GPR41) induce GLP-1 Secretion [159]

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Together, human and animal research converge to implicate the DAergic system in reversal learning from RPEs but human in vivo imaging evidence that spatially and temporally associates striatal DA release with the encounter of RPEs and evidence for individual differences in DA release as a correlate of reversal learning success is lacking

This suggests that GLP-1 receptor activation alone may not substantially increase deficiency risk

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Hart RJ