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Across studies, fat mass decline predominated, whereas reductions in lean body mass were modest

Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

The results of a Phase II clinical trial have demonstrated significant weight reduction in overweight and obese adults

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Glucagon-like peptide 1 (GLP1) receptor agonists reduce the rate of major adverse cardiovascular events in people with type 2 diabetes mellitus