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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

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The biggest gap is that we know relatively little about the real-world health effects of these peptides because most have not been studied in rigorous human clinical trials, Jason Nagata, M.D., associate professor of pediatrics at the University of California in the US, tells us