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Varin EM, Mulvihill EE, Baggio LL, Koehler JA, Cao X, Seeley RJ, Drucker DJ

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Tirzepatide A once-weekly subcutaneous single-molecular dual agonist (GLP-1 and GIP), tirzepatide has a binding affinity for the GLP-1 receptor that is five times lower than that of native GLP-1 and a similar affinity for the GIP receptor has a binding affinity for the GLP-1 receptor that is five times lower than that of native GLP-1 and a similar affinity for the GIP receptor as native GIP [95], a finding subsequently corroborated by additional investigations