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This increase in free intracellular Ca 2+ from intracellular stores permits enhanced granule exocytosis leading to enhanced insulin secretion

GLP-1Rs are minimally present in cardiac and vascular tissues and are nearly absent on enterocytes

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New research from 2025 continues to demonstrate its effectiveness, particularly when compared to other GLP-1 medications like tirzepatide

In addition, the interconnected and dynamic nature of metabolic, inflammatory and fibrotic aspects of the disease, in response to an intervention, add to the difficulty in identifying clear and precise endpoints

Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes