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Nonetheless, in line with a role for PDX1 in age-related changes in GIP secretion, suppression of PDX1 using intestine-specific gene transfer in mice reduces K-cell number, Gip expression and GIP content in the small intestine [192]

Future research is likely to focus on how this signalling pathway can be better manipulated to enhance insulin action in insulin sensitive tissues without inducing off-target effects

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18 Therefore, plastic surgeons must consider abrupt rebound weight gain with medication cessation, as this may compromise long-term aesthetic results and patient satisfaction

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