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In the clinical trials of tirzepatide, 19% of older adults had constipation while using the drug, compared with about 6% of those on a placebo

[1] [5] These medications bind to GLP-1 receptors primarily in the pancreas, brain, and gastrointestinal tract, leading to increased insulin secretion, reduced glucagon release, and enhanced satiety

Authors Ariana Eunjung Cha and Aaron Steckelberg refer to a Department of Veterans Affairs study, based on the data of 2.5 million patients, that found that people prescribed GLP-1 drugs had a lower relative risk of developing dementia compared with those who took other drugs for diabetes. Another study based on the medical records of over 100 million patients found that Ozempic was linked to a lower risk of cognitive problems. A study of liraglutide, an older GLP-1, found patients had slower cognitive decline than those not on the drug, and liraglutide appeared to reduce shrinkage in key parts of the brain. However, Novo Nordisk recently announced that its two clinical trials of semaglutide for dementia or mild cognitive impairment showed no cognitive benefits

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Strengths of this study included the sizable nondiabetic population in the database

These naturally occurring compounds in the body play a critical role in controlling hunger, increasing fat burning, and improving overall weight loss