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2018;67[Suppl 1]:522-P

In the study of people with obesity due to LEPR deficiency, IMCIVREE reduced their weight and hunger, too

61 Additionally, metabolic molecules can act directly in the brain to trigger efferent output that regulates metabolic homeostasis (Figure 3)

Dudas, E

These changes were accompanied by preservation of structural proteins including aggrecan and collagen II, along with reduced caspase-3mediated apoptosis, suggesting a coordinated reduction in glycation-driven cellular stress and tissue degradation

Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo