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Since tirzepatide is a dual GLP1R/GIPR agonist, the interpretation is compelling: GIP receptor activation normally buffers the nausea-inducing effects of GLP-1 agonism, and when that buffer is genetically impaired, the GLP-1 component goes unchecked

Researchers examined data from more than 9,000 patients, sharing their findings at SCAI 2025.

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Noticing sweet, fruity, or unusual urine odour